Several solutions have been sought for the eradication of the Coronavirus since its outbreak. Various companies are developing solutions that include using Cannabidiol (CBD). One of such companies is STERO Biotechs, a research and development start-up that is committed to the research and development of CBD based treatment solutions that will potentially benefit millions of patients. STERO works to attain additional knowhow in it to seek simpler treatments for COVID-19 patients, amongst other conditions.
CBD and COVID-19: Friends or Foes?
A lot of literature has been written on CBD and cannabis as they can serve as potential treatments for COVID-19. It is necessary to grasp that, depending on the stage of the illness, cannabinoids (CBD) might either facilitate or damage a patient. This is because every point of the illness is probably going to need a completely different treatment. In the early stages, patients should mount associate degree immunologic response to combat the virus therefore their system should be at its best.
In the final stages, however, if a patient with a severe case of Coronavirus develops a cytokine storm, the immunological function of cannabinoids (CBD) can be used to fight off these harmful cytokine disorders which often have fatal effects. Evaluating the safety and efficaciousness of isolated cannabinoids or Cannabis normally, at numerous stages of a COVID-19 infection in clinical settings, is the key.
With the world and health analysis community urgently sorting out a preventative or a potential vaccine/cure for the coronavirus (OPERATION WARP SPEED), a pool of university and personal researchers in North America have uncovered preliminary proof that cannabis might hold the key in developing a widely available, comparatively cheap and sensible preventative treatment for coronavirus. According to the official analysis abstract, the analysis team believes it is incontestable that prime concentrations of CBD extract will facilitate, modulate, and suppress the transmission of active COVID-19 virus pathogens from the mouth, nose, and lungs to an infected person.
How CBD helps the lung
CBD seems to reduce the "cytokine storm" that damages the lungs killing several patients with COVID-19 by sanctioning a rise in levels of natural amide (peptides) known as apelin, which is known to reduce inflammation and whose levels are dramatically reduced in the face of this cytokine storm.
Researchers at the Augusta Medical University in Georgia, USA, reported that CBD has the ability to enhance the oxygen levels in our lungs and reduce inflammation, as well as reduce physical lung damage in its laboratory model of deadly adult respiratory distress syndrome known as ARDS. Now their research has shown that apelin levels are going way down with the viral infection, which has killed more than 1 million people worldwide, and that CBD helps rapidly normalize those levels along with lung function.
Blood levels of the peptide fell close to zero in ARDS ( Adult Respiratory Distress Syndrome) pattern and increased 20 times with CBD, as reported in the Journal of Cellular and Molecular Medicine. Apelin is a penetrating peptide made by cells in the heart, lung, brain, fat tissue, and blood, and it is an important regulator in bringing blood pressure and inflammation down. When our blood pressure gets high, for example, apelin levels must go upwards in the right place, like the cells that line the blood vessels, to help bring them down. Apelin also helps to normalize the significant increases in inflammation in the lungs and related breathing difficulties associated with adult respiratory distress syndrome (ARDS).
But when they looked at their ARDS model, apelin did not reduce the inflammation of the lung but instead decrease the lung tissue itself and the general circulation - until they administered CBD. They announced in the journal about Hemp and Cannabinoid Research that CBD treatment reduced excessive lung inflammation, enabling improvements in lung function, healthier oxygen levels, and the repair of some of the structural damage to the lungs that they are classics with ARDS. The researchers said more work was needed then, including finding how CBD produced the important changes as well as human trials before it must be included as part of a treatment regimen for COVID-19. Now they have connected these improvements with the apelin rule.
While they don't attribute the benefits of all CBD to apelin, it is said that the peptide has an important role in this. It is still not known if CBD has a direct effect on apelin, or if these are downstream consequences. Coronavirus enters human cells via the angiotensin-converting enzyme 2 (ACE2) receptor and there is a lot of common ground between ACE2 and apelin. The study shows that the virus probably suppresses the apelin, and CBD interferes and helps increase the apelin level.
Researchers say that the next constructive steps include a higher understanding of the interaction and relationship between CBD, apelin, and coronavirus together with why apelin goes down within the face of the virus and the reason why CBD brings the apelin up. Some researchers already highlighted CBD's ability to boost oxygen levels and cut back inflammation, as well as physical respiratory organ (lung) damage in their laboratory model of adult fatal metabolism distress syndrome (ARDS).