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As with every vitamin, mineral, and herbal supplement, CBD occasionally may cause some minor side effects. Any substance has the potential to affect different people in a variety of different ways. Before you start taking CBD as part of your daily regimen, it’s important to be aware of possible side effects. It’s recommended that you discuss using CBD with your doctor or health professional, particularly if you are taking on a regular medication program.
CBD has the potential to cause a dry mouth, even if the method of administration has nothing to do with smoking or vaporizing. In fact, CBD can cause a dry mouth via its interaction with the Endocannabinoid system. By affecting cannabinoid receptors on the salivary glands, CBD can reduce the secretion of saliva, thereby causing a dry mouth. Although this might feel a little uncomfortable, it's easily remedied by carrying around a bottle of water or juice after you've taken some CBD.
Studies seem to show that although CBD doesn’t cause any major, sustained changes in blood pressure, it can cause a temporary reduction. For most people, this alteration will go completely unnoticed; however, for those with certain health conditions, even a small drop in blood pressure can be significant.
Other possible but rare side effects of CBD include light-headedness and drowsiness. Some users claim to feel more awake and alert after administering a dose, whereas others start to feel more relaxed and sleepy. In the same way, certain users report feeling lightheaded, which, again, may be associated with a small drop in blood pressure. Because of these possible side effects, it's important for users to start out with a low CBD% dose for the first 3-4 weeks and then gradually increase the CBD% dose after seeing how CBD affects them, and to obtain the benefit you are seeking. It also makes sense to avoid driving or operating heavy machinery, for an hour or so, after taking CBD for the first few times.
A 2017 paper states that CBD may cause a possible range of side effects when taken in conjunction with certain pharmaceutical drugs. This is because the cannabinoid interacts with drug-metabolising enzymes, including those belonging to the cytochrome P450 family. Once CBD is metabolised by P450, it ends up essentially displacing the enzymes and preventing them from metabolising other drugs. This can result in higher levels of other drugs sustained in the body for longer periods. Individuals taking any medication should consult their doctor before taking CBD.
Most of the current research on CBD's potential side effects is the result of in vitro (involving cells) and animal-based studies. More human research is required to come to accurate conclusions regarding the possible side effects of CBD, especially in contested domains like those mentioned above. A paper published within the journal “Cannabis and Cannabinoid Research” discusses the problem with comparing animal and human research outcomes. In humans, CBD is often administered orally or via inhalation. In rodents, CBD is seldom administered orally and usually by injection. Test results attained in animals should not automatically be accepted as being the same in humans.
Additionally, the blood concentrations of CBD within humans and rodents differ upon oral administration. Even if the same blood concentrations are achieved between species, CBD may have varying biological effects. So far, the safety profile of CBD is high; however, in-depth human research is important.
In today's modern age, it is not uncommon for us to take a variety of different medications. Given CBD’s influence on several biological systems, knowing whether it can be taken alongside these regular medications is an important topic. Keep reading for everything you need to know.
The different ways in which CBD can positively support the body continue to be unveiled, but one factor remains constant—the compound’s favorable safety record. CBD is well tolerated, even in doses of up to 160mg a day, with minimal, if any, side effects. To put that in perspective, an average dose of CBD Oil is 3–4 drops three times a day or 5-6 drops morning and night, this totals approximately 24mg/day of CBD (based on BWell’s CBD 4% CBD Oil).
Furthermore, the compound has been acknowledged as possessing a good level of safety by The World Health Organisation after they conducted an in-depth review. Their conclusion of current CBD research was the following:
“CBD is generally well tolerated with a good safety profile. Reported adverse effects may be the result of drug-drug interactions between CBD and patients’ existing medications”.
The review took into account a broad range of research papers, alongside clinical and preclinical trials. Their findings are encouraging because it outlines that, based on what we currently know, the side effects of CBD are indeed minimal. You can read more about what those potential side effects might be here. However, it is important not to disregard that these side effects may be the result of drug-drug interactions. The critical part of their statement is the word “may”, as it indicates that we still don’t fully understand every possible interaction or complication that could occur inside the human body.
CBD, like many forms of medication, needs to be metabolised by the liver before it can be distributed around the body. Once the digestive system has processed CBD, it will go through a “first-pass” process in the liver. It is at this point that the liver uses special enzymes to help break the CBD down into smaller core components (metabolites) and distribute them around the body via the circulatory system. This process is perfectly natural.
The potential problem with CBD is that when it is consumed alongside other medication, it basically takes all of the liver's attention. The special enzymes we mentioned, specifically the cytochrome P450 enzyme, becomes distracted by CBD, and this can stop it from breaking down any other medication present into smaller parts. This is where adverse effects can occur. If certain medications are left in the body for longer than they should be, the body could start to experience side effects.
Research into the potential interaction between CBD and medication is ongoing
Any drug that is metabolised by the P450 enzyme could be affected by CBD. Many types of steroids, antibiotics, antidepressants, beta blockers, and antihistamines fall into that category, amongst several other forms of medication. However, just because these types of medication are broken down by enzymes in the liver doesn't mean that interaction with CBD will definitely occur. When deciding to take CBD, you should always consult your doctor first, especially if you have concerns about its impact on your present prescribed medications, if in fact you are currently on prescribed medications.